• Anthracyline regimens are safe
• There are fewer data on taxanes, which should be reserved for high-risk (node-positive) or metastatic disease.
• Tamoxifen is not used until after delivery.
• Trastuzumab  is contraindicated during pregnancy.
• Haemopoietic growth factors (granulocyte colony stimulating factor) may be employed to ameliorate chemotherapy-induced neutropenia.

With Remifentanyl PCA- Respiratory depression is reported in up to 32% of patients and
oxygen saturations below 90% are seen in about 5%.

Some suggested contraindications of Remifentanyl PCA include- morbid obesity, clinical features of a chest infection and primigravida women who are at risk of prolonged labour.

The correct answer is- 11 g/ 100 ml at first contact and 10.5 g/100 ml at 28 weeks.

Haemoglobin outside this range should be investigated and iron supplementation considered if indicated.

Pregnant women should be offered screening for anaemia. Screening should
take place early in pregnancy (at the booking appointment) and at 28 weeks
when other blood screening tests are being performed. This allows enough time
for treatment if anaemia is detected.

Source- 1. NICE  Antenatal care for uncomplicated
pregnancies
Clinical guideline
Published: 26 March 2008

2. RCOG Green-top Guideline No. 52

People who are concerned about their fertility should be informed that over
80% of couples in the general population will conceive within 1 year if:
- the woman is aged under 40 years and
- they do not use contraception and have regular sexual intercourse.
Of those who do not conceive in the first year, about half will do so in the second year
(cumulative pregnancy rate over 90%).

Systemic chemotherapy is contraindicated in the first trimester because of a high rate of fetal
abnormality,but is safe from the second trimester.

The diagnostic criteria of DKA are-

bocarb

glucose