NSAIDs can lead to neonatal pulmonary hypertension and premature closure of the ductus arteriosus.

NSAIDs also reduce fetal renal blood flow and thus urine production leading to a reduced amniotic fluid volume.

The use of NSAIDs should, therefore, be avoided at more than 30 weeks of gestation.

Undertake a urine dipstick test in all women presenting with urinary
incontinence to detect the presence of blood, glucose, protein, leucocytes and nitrites in the urine.

Use bladder diaries in the initial assessment of women with urinary
incontinence or overactive bladder.

Encourage women to complete a minimum of 3 days of the diary covering variations in their usual activities, such as both working and leisure days.

If the placenta is thought to be low lying (less than 20 mm from the internal os) or praevia
(covering the os) at the routine fetal anomaly scan, a follow-up ultrasound examination
including a TVS is recommended at 32 weeks of gestation to diagnose persistent low-lying
placenta and/or placenta praevia.

Use of TVS- to accurately see the placental edge. Also, cervical length is a predictor of antepartum bleeding and emergency preterm caesarean section in placenta praevia. Women with a cervical length of less than 31 mm have a 16 times higher risk of emergency
caesarean section due to massive haemorrhage.

According to Guidance from the British Committee
for Standards in Haematology, it is greater than 2 gram/dL

If women do not achieve satisfactory benefit from bladder training programmes, the combination of an overactive bladder medicine with bladder training should be considered if frequency is a troublesome symptom.

• Anthracyline regimens are safe
• There are fewer data on taxanes, which should be reserved for high-risk (node-positive) or metastatic disease.
• Tamoxifen is not used until after delivery.
• Trastuzumab  is contraindicated during pregnancy.
• Haemopoietic growth factors (granulocyte colony stimulating factor) may be employed to ameliorate chemotherapy-induced neutropenia.