ABG Analysis is of limited value in diagnosis of PE.

In one study- ABG analysis showed that only 10% had arterial P O2 levels less than 60 mmHg and 2.9% had oxygen saturation levels less than 90%.

Systemic chemotherapy is contraindicated in the first trimester because of a high rate of fetal
abnormality,but is safe from the second trimester.

• Anthracyline regimens are safe
• There are fewer data on taxanes, which should be reserved for high-risk (node-positive) or metastatic disease.
• Tamoxifen is not used until after delivery.
• Trastuzumab  is contraindicated during pregnancy.
• Haemopoietic growth factors (granulocyte colony stimulating factor) may be employed to ameliorate chemotherapy-induced neutropenia.

Treatment with therapeutic doses of subcutaneous LMWH should be employed during the remainder of the pregnancy and for at least 6 weeks postnatally and until at least 3 months of treatment has been given in total.

For anti-K antibodies, referral should take place once detected, as severe fetal anaemia can occur even with low titres.

Obstetric patients who are postoperative and receiving unfractionated heparin should have platelet count monitoring performed every  2 to3  days from days 4 to 14 or until heparin is stopped.

The platelet count should be checked after 24 hours of initiating treatment if the patient has previously received heparin (unfractionated or LMWH) in the last 100 days.

Up to 10% of women scheduled for ERCS go into labour before
39+0 weeks. Therefore it is good practice to to discuss and document a plan for delivery if labour starts prior to the scheduled date.

• If pharmacological measures fail to control the haemorrhage, surgical interventions should be initiated sooner rather than later.
• Intrauterine balloon tamponade is an appropriate first-line ‘surgical’ intervention for most women where uterine atony is the only or main cause of haemorrhage.