Replacing intramuscular ceftriaxone with an oral cephalosporin (e.g. cefixime) is      not recommended because there is no clinical trial evidence to support its use, and tissue levels are likely to be lower
which might impact on efficacy. Reports of decreasing susceptibility of N. gonorrhoeae to cephalosporins also supports the use of parenteral based regimens when gonococcal PID is suspected (to maximise tissue levels and overcome low level resistance)